Michael John Kimber

PhD
Chair and Professor
Biomedical Sciences
5152944415
2024 Patterson Hall
ISU Directory Link
Kimber Lab website
Education & Certifications  

• PhD, Molecular Parasitology, 2001, Queen's University Belfast, Belfast, UK

• BSc, Biological Sciences, 1998, Queen's University Belfast, Belfast, UK

Teaching  
  • 2013-present                       Instructor, Principles of Physiology (BMS 538, Graduate Curriculum)
  • 2009-present                       Instructor, Topics in Molecular Veterinary Medicine (BMS 353, Professional Curriculum)
  • 2008-2013                          Instructor, Advanced Vertebrate Physiology II (BMS 552, Graduate Curriculum)
  • 2006-present                      Instructor-in-charge, Physiology and Functional Anatomy of Domestic Animals (BMS 329, Undergraduate Curriculum)
  • 2006-present                      Instructor, Biomedical Sciences I (BMS 333, Professional Curriculum) Urinary System Physiology
  • 2005-2011                          Instructor, Advanced Techniques in Neuroscience (Neuro 557, Graduate Curriculum)
  • 2004                                   Invited Lecturer, Case Study I (BMS 345, Professional Curriculum) Clinical applications of basic sciences.
  • 1998-2001                          Teaching Assistant, Animal Physiology (110BBC201) Queen’s University Belfast, Belfast, UK
  • 1998-2001                          Teaching Assistant, Invertebrate Biology (210BBC223) Queen’s University Belfast, Belfast, UK
Research Focus & Interests  

Neuromuscular biology of parasitic worms, and in particular the role played by small molecule transmitters, in an effort to identify novel targets for antiparasitic drugs. We are also increasingly focused on the importance of small, non-coding RNAs for worm biology and how they might play a role at the host-parasite interface.

Honors & Awards  
  • Mid-Career Achievement in Research Award, Iowa State University College of Veterinary Medicine, 2014
Selected Publications  

Link to PubMed

Peer-Reviewed Publications

  1. Environmental Neurotoxicant Manganese Regulates Exosome-mediated Extracellular miRNAs in Cell Culture Model of Parkinson's Disease: Relevance to alpha-Synuclein Misfolding in Metal Neurotoxicity. Harischandra D.S., Ghaisas S., Rokad D., Zamanian M., Jin H., Anantharam V., Kimber M.J., Kanthasamy Ar. and Kanthasamy An. Neurotoxicology, in review.
  2. Environmental Neurotoxicant Manganese Regulates Exosome-mediated Extracellular miRNAs in Cell Culture Model of Parkinson's Disease: Relevance to alpha-Synuclein Misfolding in Metal Neurotoxicity. Harischandra D.S., Ghaisas S., Rokad D., Zamanian M., Jin H., Anantharam V., Kimber M.J., Kanthasamy Ar. and Kanthasamy An. Neurotoxicology, in review.
  3. Essential oils enhance the toxicity of permethrin against Aedes aegypti and Anopheles gambiae. Gross A.D., Norris E.J., Kimber M.J., Bartholomay, L.C. and Coats J.R. Medical and Veterinary Entomology, available online Dec 2016 doi: 10.1111/mve.12197.
  4. Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target. Gross A.D., Temeyer K.B., Day T.A., Perez de Leon A.A., Kimber M.J. and Coats J.R. Chemico-Biological Interactions, online doi: 10.1016/j.cbi.2016.12.009
  5. A constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni. MacDonald K., Kimber M.J., Day T.A. and Ribeiro P. Molecular & Biochemical Parasitology, 202,29-37.
  6. Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi. Zamanian M., Fraser L.M., Agbedanu P., Harischandra H., Moorhead A.R., Day T.A., Bartholomay L.C. and Kimber M.J. PLoS Neglected Tropical Diseases, 9(9): e0004069. doi:10.1371/journal.pntd.0004069 (Featured article, widely publicized including coverage on BBC science podcast “The Naked Scientists”)
  7. Gene regulatory network inference from perturbed time-series expression data via ordered dynamical expansion of non-steady state actors.  Zamanighomi M., Zamanian M., Kimber M.J. and Wang Z.  IEEE/ACM Transactions on Computational Biology and Bioinformatics. 99, 1. doi: 10.1109/TCBB.2015.2509992
  8. Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus. Gross A.D., Temeyer K.B., Day T.A., Perez de Leon A.A., Kimber M.J., Coats J.R. Insect Biochemistry and Molecular Biology 63, 47-53.
  9. G Protein-coupled receptors (GPCRs) as biopesticide targets: a focus on octopamine and tyramine receptors. Gross A.D., Kimber M.J. and Coats J.R. In: Biopesticides: State of the art and future opportunities. Gross, Coats, Duke and Seiber (Eds), American Chemical Society Symposium Series 1172, 45-56.
  10. Functional analysis of Girardia tigrina transcriptome seeds pipeline for anthelmintic target discovery.  Wheeler N.J., Agbedanu P.N., Kimber M.J., Ribeiro P., Day T.A. and Zamanian M.  Parasites and Vectors 8:34.  doi:10.1186/s13071-014-0622-3
  11. Functional characterization of a novel family of acetylcholine-gated chloride channels in Schistosoma mansoni.  MacDonald K., Buxton S., Kimber M.J., Day T.A. and Ribeiro P.  PLoS Pathogens 10(6): e1004181. doi:10.1371/journal.ppat.1004181.
  12. New insights into the FLPergic complements of parasitic nematodes: Informing deorphanization approaches.  McCoy C.J., Atkinson L.E., Zamanian M., McVeigh P., Day T.A., Kimber M.J., Marks N.J., Maule A.G. and Mousley A. EuPA Open Proteomics 3,262-272.
  13. Involvement of a putative intercellular signal-recognizing G protein-coupled receptor in the engulfment of Salmonella by the protozoan Tetrahymena.  Agbedanu P.N., Brewer M.T., Day T.A., Kimber M.J., Anderson K.L., Rasmussen S.K., Rasmussen M.A. and Carlson S.A. Open Veterinary Journal, 3(2): 69-74.
  14. Quantitative structure-activity relationships (QSARs) to describe monoterpenoid activity at the American cockroach octopamine receptor, Pa oa1.  Gross A.D., Kimber M.J., Day T.A., Riberio P. and Coats J.R.  In “Pest Management with Natural Products” Beck J.J. et al. (Eds.), ACS Symposium Series Books, Washington, DC. pp97-110.
  15. flp-32 ligand/receptor silencing phenocopy a faster phenotype in plant pathogenic nematodes.  Atkinson L.E., Stevenson M., McCoy C., Maule A.G., Marks N.J., Fleming C.C., Zamanian M., Day T.A., Kimber M.J. and Mousley A. PLoS Pathogens, 9(2): e1003169.
  16. Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor.  Zamanian M., Agbedanu P.N., Wheeler N.J., McVeigh P., Kimber M.J. and Day T.A. PLoS One, 7(7):e40787.
  17. The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea.  Zamanian M., Kimber M.J., McVeigh P., Carlson S.A., Maule A.G. and Day T.A.  BMC Genomics 12:596. doi:10.1186/1471-2164-12-596
  18. Beta-lactam antibiotics prevent Salmonella-mediated bovine encephalopathy regardless of the β-lactam resistance status of the bacteria.  Xiong N., Brewer M.T., Anderson K.L., Watrous G.K., Weeks K.E., Barnhill A.E., Day T.A., Kimber M.J. and Carlson S.A. The Veterinary Journal, 192(3):535-7.
  19. Schistosome I/Lamides – A new family of bioactive helminth neuropeptides.  McVeigh P., Mair G.R., Novozhilova E., Day A., Zamanian M., Marks N.J., Kimber M.J., Day T.A. and Maule A.G. International Journal of Parasitology. 41, 905-913.
  20. Probing the function of schistosome Sm-npp-1 exposes a new family of helminth neuropeptides. McVeigh P, Mair GR, Novozhilova E, Day A, Zamanian M, Marks NJ, Kimber MJ, Day TA, Maule AG. Regulatory Peptides 164(1):27. doi: 10.1016/j.regpep.2010.07.060.
  21. Schistosoma mansoni neuropeptide amidating enzymes. Atkinson LE, McVeigh P, Marks NJ, Kimber MJ, Day TA, Eipper BA, Mains RE, Maule AG. Regulatory Peptides 164(1):27. doi: 10.1016/j.regpep.2010.07.060
  22. Neuropeptide Physiology in Helminths.  Mousley A., Novozhilova E., Kimber M.J. and Day T.A. Advances in Experimental Medicine and Biology.692, 78-97.
  23. Development of an In Vivo RNAi Protocol to Investigate Gene Function in the Filarial Nematode, Brugia malayi.  ong C., Gallup J.M., Day T.A., Bartholomay L.C. and Kimber M.J. PLoS Pathogens 6(12): e1001239. doi:10.1371/journal.ppat.1001239
  24. Evaluation of the pathogenicity and virulence of three strains of Salmonella organisms in calves and pigs.  Xiong N., Brewer M.T., Day T.A., Kimber M.J., Barnhill A.E. and Carlson S.A.  American Journal of Veterinary Research. 71, 1170-1177.
  25. FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.  Novozhilova E., Kimber M.J., Qian H., McVeigh P., Robertson A.P., Zamanian M., Maule A.G. and Day T.A.  PLoS Neglected Tropical Diseases, 4, e790.
  26. A PAL for Schistosoma mansoni PHM.  Atkinson L.E., McVeigh P., Kimber M.J., Marks N.J., Eipper B.A., Mains R.E., Day T.A. and Maule A.G. Molecular and Biochemical Parasitology. 173, 97-106.
  27. Identification of an Ascaris G protein-coupled receptor with atypical muscarinic pharmacology.  Kimber M.J., Sayegh L., El-Shahabi F., Song C., Zamanian, M., Woods D.J., Day T.A. and Ribeiro P. International Journal for Parasitology, 39, 1215-1222.
  28. Somatostatin receptors signal through efa6a-arf6 to activate phospholipase D in clonal β-cells.  Grodnitzky J.A., Syed N., Kimber M.J., Day T.A., Donaldson J.G. and Hsu W.H. Journal of Biological Chemistry, 282, 13410-13418.
  29. Getting to the root of neuronal signalling in plant-parasitic nematodes using RNA interference.  Fleming C.C., McKinney S., McMaster S., Johnston M.J.G., Donnelly P., Kimber M.J. and Maule A.G. Nematology, 9, 301-315.
  30. flp Gene disruption in a parasitic nematode reveals motor dysfunction and unusual sensitivity to RNA interference.  Kimber M.J., McKinney S., McMaster S., Day T.A., Fleming C.C. and Maule A.G. FASEB Journal, 21, 1233-1243.
  31. Identification of a platyhelminth neuropeptide receptor.  Omar H.H., Humphries J.E., Larsen M.J., Kubiak T.M., Geary T.G., Maule A.G., Kimber M.J. and Day T.A. International Journal for Parasitology, 37, 725-733.
  32. Neuromuscular function in plant parasitic nematodes: a target for novel control strategies?  Kimber M.J. and Fleming C.C. Parasitology 131, S129-142.
  33. Neuropeptide Signalling Systems in Flatworms.  McVeigh P., Kimber M.J., Novozhilova E. and Day T.A.  Parasitology 131, S41-55.
  34. Structure and Bioactivity of Neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum.  Humphries J.E., Kimber M.J., Barton Y-W, Hsu W., Marks N.J., Greer B., Harriott P., Maule A.G. and Day T.A. Journal of Biological Chemistry 279, 39880-5.
  35. Localisation of Globodera pallida FMRFamide-related peptide encoding genes using in situ hybridization.  Kimber M.J., Fleming C.C., Prior A., Jones J.T., Halton D.W. and Maule A.G.  International Journal of Parasitology 32, 1095-105.
  36. FMRFamide-related peptides in potato cyst nematodes.  Kimber M.J., Fleming C.C., Bjourson A.J., Halton D.W. and Maule A.G. Molecular and Biochemical Parasitology 116, 199-208.
  37. Classical neurotransmitters in the ovijector of Ascaris suum: localisation and modulation of muscle activity.  Fellowes R.A., Maule A.G., Martin R.J., Geary T.G., Thompson D.P., Kimber M.J., Marks N.J. and Halton D.W. Parasitology 121, 325-336.
  38. Functional ryanodine receptor channels in flatworm muscle fibers.  Day T.A., Haithcock J., Kimber M. and Maule A.G. Parasitology 120, 417-422.